Splenda, Sucralose Artificial Sweetener, Could Affect Body’s Insulin Response

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A new study may make you think twice before adding Splenda to your coffee.

Published in the journal Diabetes Care,
Washington University School of Medicine in St. Louis researchers found
that sucralose, most popularly known by the brand name Splenda, has
effects on the body’s responses to sugar (glucose) — which could
thereby affect diabetes risk — despite the fact that it has zero

“Our results indicate that this artificial sweetener is not inert
it does have an effect,” study researcher M. Yanina Pepino, Ph.D.,
research assistant professor of medicine at the university, said in a
statement. “And we need to do more studies to determine whether this
observation means long-term use could be harmful.”

The new study included 17 people who were severely obese (they had a
body mass index over 42; 30 is considered the starting point for
obesity) and who didn’t regularly consume artificially sweetened
products. The study participants drank sucralose or water before taking a
glucose challenge test. This test involves drinking a sugary solution
before undergoing blood sugar measurements in order to see how well the
body responds to sugar; it’s typically used as a tool to determine if a
woman has gestational diabetes, according to the Mayo Clinic.

After that, the researchers asked all the study participants who
first drank water to then drink sucralose before undergoing another
glucose challenge test, and all those who first drank sucralose to then
drink water before undergoing another glucose challenge test.
Researchers found that consuming the sucralose was associated with
higher blood sugar peaks and 20 percent higher insulin levels
compared with consuming the water, though they noted more studies are
needed to determine the actual health effects of a 20 percent increase
in insulin.

It’s important to understand how exactly insulin and blood sugar play a role in Type 2 diabetes.
Insulin is a hormone produced by the pancreas that assists in the
absorption of sugar into cells and also helps to decrease the amount of
sugar that is circulating in the blood. The amount of insulin secreted
into the bloodstream is related to the amount of sugar circulating; when
there is less sugar, there is less insulin being secreted, according to
the Mayo Clinic. With Type 2 diabetes, cells become insulin-resistant,
and the pancreas isn’t able to produce enough insulin to get the cells
to take up the sugar. When this happens, sugar accumulates in the blood.

The increases in insulin levels in the new study could show that the participants’ bodies are able to produce insulin to accommodate the glucose — or
it could be a risk factor for diabetes because when a body is
constantly secreting insulin, it raises the risk of cells becoming
resistant to the hormone.

But still, even though “we found that sucralose affects the glucose and insulin response
to glucose ingestion, we don’t know the mechanism responsible,” Pepino
said in the statement. “We have shown that sucralose is having an
effect. In obese people without diabetes, we have shown sucralose is
more than just something sweet that you put into your mouth with no
other consequences.”

Past research in animals has suggested that artificial sweeteners
have effects on fasting glucose levels. Particularly, research presented
at a 2011 meeting of the American Diabetes Association showed that
aspartame — another kind of artificial sweetener — is linked with higher fasting glucose levels in mice, TIME reported.

And Dr. Melina Jampolis, who is an internist and physician nutrition
specialist, told CNN in a Q&A that the jury is still out about
whether having that sweet taste in your mouth — even if it’s from
artificial sweeteners and not from sugar — triggers the brain to want more calories. She said:

The taste of sweet does cause the release of insulin, which
lowers blood sugar, and if carbohydrates are not consumed, it causes a
drop in blood sugar which triggers hunger and cravings for sugar. So if
an artificial sweetener is consumed alone, it could theoretically
increase hunger. However in the context of a meal, it is not known if
it causes an increase in hunger and if so, it’s not known if this
outweighs the decrease in calories consumed. We know that some
artificial sweeteners do cause a release of insulin which could drop
your blood sugar and make you crave more sugar actually. And they also
seem to trigger the same addition like pathways in the brain.

As far as a link between a big source of artificial sweeteners —
diet drinks — and diabetes, research has been a little more mixed. A
study presented at the same American Diabetes Association meeting showed
that diet soda-drinkers had dramatically bigger waistlines
over a nearly 10-year period, compared with non-diet soda drinkers —
and weight is, of course, a huge risk factor for diabetes.

And a study released earlier this year in the American Journal of
Clinical Nutrition showed an association between diet soda and higher
Type 2 diabetes risk. That research interestingly showed that while diet
and regular soda drinkers had higher Type 2 diabetes risks, those who
imbibed with diet had an even higher diabetes risk.

However, a big study in the American Journal of Clinical Nutrition published in 2011 showed that diet sodas actually may not raise diabetes risk, and that the association could be attributed to the fact that people with diabetes or who are obese drink more diet drinks than other people, Reuters reported.

“People who are at risk for diabetes or obesity … those may be the people who are more likely to choose artificial sweeteners
because they may be more likely to be dieting,” National Institutes of
Health endocrinologist Rebecca Brown, an artificial sweetener researcher
who was not involved in the 2011 study, told Reuters.

But still, there’s no question that some good old H2O trumps sodas — diet or not — to quench thirst and hydrate the body.