Prolonged
sleep disturbance can lead to lower bone formation

Date:

April 2, 2017

Source:

The Endocrine Society

Summary:

Insufficient sleep, a common problem that
has been linked to chronic disease risk, might also be an unrecognized risk factor
for bone loss.

Insufficient sleep, a common problem that has been linked
to chronic disease risk, might also be an unrecognized risk factor for bone
loss. Results of a new study will be presented Saturday at the Endocrine
Society’s 99th annual meeting in Orlando, Fla.

Study subjects stayed in a lab, where for
three weeks they went to sleep each day four hours later than the prior day,
resulting in a 28-hour “day.” Swanson likened this change to
“flying four time zones west every day for three weeks.” The men were
allowed to sleep only 5.6 hours per 24-hour period, since short sleep is also
common for night and shift workers. While awake, the men ate the same amounts
of calories and nutrients throughout the study. Blood samples were obtained at
baseline and again after the three weeks of sleep manipulation for measurement
of bone biomarkers. Six of the men were ages 20 to 27, and the other four were
ages 55 to 65. Limited funding prevented the examination of serum from the
women in this study initially, but the group plans to investigate sex
differences in the sleep-bone relationship in subsequent studies.

After three weeks, all men had
significantly reduced levels of a bone formation marker called P1NP compared
with baseline, the researchers reported. This decline was greater for the
younger men than the older men: a 27 percent versus 18 percent decrease. She
added that levels of the bone resorption marker CTX remained unchanged, an
indication that old bone could break down without new bone being formed.

“These data suggest that sleep
disruption may be most detrimental to bone metabolism earlier in life, when
bone growth and accrual are crucial for long-term skeletal health,” she
said. “Further studies are needed to confirm these findings and to explore
if there are differences in women.”

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