Each of us is genetically and biochemically unique. But none of us are perfect. We all have some kind of genetic weakness. For example, you might have a genetic abnormality in methionine metabolism called homocystinuria (methionine is an amino acid required to make your body function). In this case, taking large doses of vitamin B6 is a way to compensate for this weakness. There are hundreds if not thousands of possible genetic abnormalities. Many of them can be minimized with dietary supplementation.