Clinic Services
Dietary Supplements
Health Concerns
Natural Treatments

Blog & Newsletters
Resources Directory

Online Forms

Email to a Friend

Bookmark this Site

Index to Our Site

CCH Health Review

This free newsletter gives you original and immediately usable information from doctors to help you build your health and vitality!
Your e-mail address is totally secure. We will never misuse or sell your information.
Clinic Services | Online Store | Health Concerns | Newsletter Archives | Contact Us

Case Study- Testimonial
Health Concerns
In the News
Newsletter Archives

Small Study Suggests Statins May Blunt Benefits Of Exercise

From Forbes Online:

A small study is raising big questions about whether statins may blunt the beneficial effects of exercise. The study has been published online in the Journal of the American College of Cardiology and was the subject of a New York Times blog today.

37 previously sedentary overweight or obese adults with at least 2 other risk factors underwent 12 weeks of aerobic exercising training. 19 patients were randomized to also receive a statin (simvastatin 40 mg/day). At the end of the study cardiorespiratory fitness, as measured by maximal oxygen uptake,  had increased significantly by 10% in the control group but only by 1.5% in the simvastatin group. The control group also had a significant 13% increase in skeletal muscle citrate synthase activity, a measure of mitochondrial activity in muscles, compared with a 4.5% decrease in the simvastatin group. The authors, led by John Thyfault at the University of Missouri, said their results "suggest that simvastatin may mitigate improvements in fitness in response to exercise training by impairing increases in skeletal muscle mitochondrial content and function."

The authors concluded: "Given the strong independent cardio-protective effects of increasing cardiorespiratory fitness or lowering LDL, the benefits and risks of each should be carefully considered when choosing treatment modalities."

The study raises troubling questions about the interactions of statins and exercise, but its small size , along with other limitations, may limit its immediate impact.