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Niacinamide for Anxiety

Barbara is a 44-year-old physician's assistant who came to me with concerns over increasing anxiety, restlessness and sleep disturbance. Her intense schedule at her medical practice certainly contributed to irregular hours and disrupted patterns of sleep as she worked in a very busy obstetrical practice. Her on-call schedule varied week to week and she was juggling this schedule with her home routine with a husband and two teenage children.

Barbara was using Ambien several nights weekly to sleep and used Xanax during the day as frequently. She was often teary and felt overly reactive to minor inconveniences and was explosive at times. Her increasing use of Xanax concerned her as she felt it offered only minimal help and she knew it was interfering with her mental focus, which she needed for her important work.

Barbara's story is a complex one and I do not mean to minimize the work she did with dietary changes, the addition of a good supplement program, and starting an exercise regimen. All these things helped a great deal, but her reliance on Ambien and Xanax went unchanged.

I had heard some interesting reports from my practice partners about the use of Niacinamide for anxiety and proposed to Barbara that we add Vital Nutrients Niacinamide 750mg 2 times daily to her current regimen. Last week, she came to the office for a follow up visit just 6 weeks after starting the Niacinamide.

I immediately knew there was a significant change in her. Even as I approached the waiting room, her smile and bright face encouraged me. She barely made it into my office before she rambled on about her success with Niacinamide. Not only was she sleeping well, but also her daily demeanor was calmer, and she felt clear headed and focused. She also had completely weaned herself off Ambien and Xanax and had been prescription free for over a month. She emphatically stated that she had not felt so well in "many years". Niacinamide is an under appreciated nutrient. This form of vitamin B3 is literally required in hundreds of enzymatic reactions in the body and is thought to be an endogenous ligand for the benzodiazepine-GABA receptor complex.